Title : Role of Calcium - activated Potassium Channels in the Genesis of 3 , 4 - diaminopyridine - induced Periodic Contractions in Isolated Canine Coronary Artery Smooth Muscles

نویسندگان

  • Yuko Maezawa
  • Yoshiro Maezawa
چکیده

Background: We found that 3,4-diaminopyridine (3,4-DAP), a voltage-gated potassium channel (K V ) inhibitor, elicits pH-sensitive periodic contractions (PCs) of coronary smooth muscles. Underlying mechanism(s) of PCs however remained to be elucidated. Purpose: The present study was performed to examine the roles of ion channels in the genesis of PCs. Methods: To determine the electromechanical changes of smooth muscles, isolated coronary arterial rings from beagles were suspended in organ chambers filled with Krebs-Henseleit solution and 10 -2

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Role of calcium-activated potassium channels in the genesis of 3,4-diaminopyridine-induced periodic contractions in isolated canine coronary artery smooth muscles.

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تاریخ انتشار 2011